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AICONS Lab

Artificial Intelligence and COmputational NeuroSciences

AICONS Lab

Our work focuses on developing novel AI/computational and neuroimaging tools to understand and predict circuit dysfunction and model brain pathology in neurological and psychiatric disorders, including Alzheimer's disease, stroke, traumatic brain injury, depression, and OCD.

Featured Work

A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

Mapping cellular targets of covalent cancer drugs in the entire mammalian body

Mapping cellular targets of covalent cancer drugs in the entire mammalian body

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease

Brain Communications

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

A generalizable 3D framework and model for self-supervised learning in medical imaging

Digital Medicine

A generalizable 3D framework and model for self-supervised learning in medical imaging

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nature Medicine

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Tau follows principal axes of functional and structural brain organization in Alzheimer's disease

Nature Communications

Tau follows principal axes of functional and structural brain organization in Alzheimer's disease

Microstructural Alterations in Tract Development in College Football and Volleyball Players

Microstructural Alterations in Tract Development in College Football and Volleyball Players

Cardiogenic control of affective behavioural state

Cardiogenic control of affective behavioural state

Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound

Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound

Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid PET

Alzheimer's & Dementia

Vascular burden and cognition: Mediating roles of neurodegeneration and amyloid PET

Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation

Human Brain Mapping

Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation

Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI

Nature Communications

Multimodal image registration and connectivity analysis for integration of connectomic data from microscopy to MRI